VH032-PEG5-C6-Cl (HaloPROTAC 2)

HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.

Signaling Pathways >> PROTAC >> PROTAC

Research Areas >> Cancer

HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1].

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.

ARV-771 | ARV-825 | dBET1 | Protein degrader 1 hydrochloride | dBET6 | Mz1 | BETd-260 | PROTAC 6 | Target Protein-binding moiety 4 | dTRIM24 | MZP-54 | PROTAC BET degrader-2 | PROTAC BRD9-binding moiety 1