BCAT-IN-2
Names
[ CAS No. ]:
1800024-45-6
[ Name ]:
BCAT-IN-2
Biological Activity
[Description]:
BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema[1].
[Related Catalog]:
[Target]
pIC50: 7.3 (BCATm), 6.6 (BCATc)[1]
[In Vitro]
BCAT-IN-2 (compound 61) inhibits BCATm in differentiated primary human adipocyte, with pIC50 of 6.5[1].
[In Vivo]
BCAT-IN-2 (compound 61) (10-100 mg/kg; p.o.) increases the level of leucine from 473 μM to 1.2 mM at the dose of 100 mg/kg in mice[1]. BCAT-IN-2 (5 mg/kg for p.o. and 1 mg/kg for i.v.) exhibits a high bioavailability (F=100%), long half-life (t1/2=9.2 h) and low clearance (Cl=0.3 mL/min/kg) in mice[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C17H14ClF2N5O
[ Molecular Weight ]:
377.78
[ Storage condition ]:
-20°C
Safety Information
[ Hazard Codes ]:
Xi