CA-4948

CA-4948 is a selective and potent IRAK4 inhibitor.

Signaling Pathways >> Immunology/Inflammation >> IRAK

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

Research Areas >> Cancer

IRAK4[1]

CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1].

[1]. Robert N. Booher, et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphoma. AACR Annual Meeting 2017; April 1-5, 2017;

IRAK-1-4 Inhibitor I | PF06650833 | ginsenoside Rb1 | IRAK4-IN-1 | IRAK inhibitor 1 | IRAK inhibitor 4 | IRAK inhibitor 2 | IRAK inhibitor 3 | IRAK inhibitor 6