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AAK1-IN-2

Names

[ CAS No. ]:
1802703-21-4

[ Name ]:
AAK1-IN-2

Biological Activity

[Description]:

AAK1-IN-2 (compound (S)-31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC50 of 5.8 nM. AAK1-IN-2 can be used for the research of neuropathic pain[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

Adaptor Protein 2-Associated Kinase 1 (AAK1)[1]


[References]

[1]. Hartz RA, et, al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H20N4

[ Molecular Weight ]:
316.40

Related Compounds