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TCO-PEG4-acid

Names

[ CAS No. ]:
1802913-21-8

[ Name ]:
TCO-PEG4-acid

[Synonym ]:
1-[(4Z)-4-Cycloocten-1-yloxy]-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oic acid
MFCD28334565
5,8,11,14-Tetraoxa-2-azaheptadecan-17-oic acid, 1-[(4Z)-4-cycloocten-1-yloxy]-1-oxo-

Biological Activity

[Description]:

TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
574.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H35NO8

[ Molecular Weight ]:
417.494

[ Flash Point ]:
301.2±30.1 °C

[ Exact Mass ]:
417.236267

[ LogP ]:
1.43

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.501

Related Compounds