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LG 100754

Names

[ CAS No. ]:
180713-37-5

[ Name ]:
LG 100754

[Synonym ]:
cd 3159

Biological Activity

[Description]:

LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

PPARα

PPARγ


[In Vitro]

LG100754 is a selective activator of endogenous RXR heterodimers[1]. LG100754 can also improve TNFα-mediated insulin resistance in mature adipocytes[1]. LG100754 acts as a bona fide activator of endogenous RXR:PPARγ heterodimers and regulator of insulin-dependent signaling pathways[1].

[In Vivo]

LG100754 (100 mg/kg) completely blocks the increase in glucose levels, suggesting that LG100754 can improve insulin resistance in vivo[1].

[References]

[1]. Cesario RM, et al. The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo. Mol Endocrinol. 2001 Aug;15(8):1360-9.

Chemical & Physical Properties

[ Density]:
1.003g/cm3

[ Boiling Point ]:
549.4ºC at 760 mmHg

[ Molecular Formula ]:
C26H36O3

[ Molecular Weight ]:
396.56200

[ Flash Point ]:
178.5ºC

[ Exact Mass ]:
396.26600

[ PSA ]:
46.53000

[ LogP ]:
6.81480

[ Vapour Pressure ]:
6.63E-13mmHg at 25°C

[ Index of Refraction ]:
1.526

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds