THP-SS-PEG1-Boc

Names

[ Name ]:
THP-SS-PEG1-Boc

[Synonym ]:
2-Methyl-2-propanyl 3-(2-{[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]disulfanyl}ethoxy)propanoate
Propanoic acid, 3-[2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]ethoxy]-, 1,1-dimethylethyl ester
MFCD28505560

Biological Activity

[Description]:

THP-SS-PEG1-Boc is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
470.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₃₀O₅S₂

[ Molecular Weight ]:
366.536

[ Flash Point ]:
222.7±16.7 °C

[ Exact Mass ]:
366.153473

[ LogP ]:
3.70

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.512

THP-SS-PEG1-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds