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Acid-PEG3-mono-methyl ester

Names

[ CAS No. ]:
1807505-26-5

[ Name ]:
Acid-PEG3-mono-methyl ester

[Synonym ]:
3-Oxo-2,6,9,12-tetraoxapentadecan-15-oic acid
2,6,9,12-Tetraoxapentadecan-15-oic acid, 3-oxo-
MFCD28015772

Biological Activity

[Description]:

Acid-PEG3-mono-methyl ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
396.7±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H20O7

[ Molecular Weight ]:
264.272

[ Flash Point ]:
145.9±18.6 °C

[ Exact Mass ]:
264.120911

[ LogP ]:
-0.72

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.454

Related Compounds