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1,1,1-Trifluoroethyl-PEG4-alcohol

Names

[ CAS No. ]:
1807512-41-9

[ Name ]:
1,1,1-Trifluoroethyl-PEG4-alcohol

[Synonym ]:
3,6,9,12-Tetraoxatetradecan-1-ol, 14,14,14-trifluoro-
MFCD28950755
14,14,14-Trifluoro-3,6,9,12-tetraoxatetradecan-1-ol

Biological Activity

[Description]:

1,1,1-Trifluoroethyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
324.8±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H19F3O5

[ Molecular Weight ]:
276.250

[ Flash Point ]:
152.6±23.0 °C

[ Exact Mass ]:
276.118469

[ LogP ]:
-1.10

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.407

Related Compounds