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3,4-Dibromo-Mal-PEG2-Amine TFA

Names

[ CAS No. ]:
1807534-86-6

[ Name ]:
3,4-Dibromo-Mal-PEG2-Amine TFA

[Synonym ]:
1H-Pyrrole-2,5-dione, 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dibromo-
1-{2-[2-(2-Aminoethoxy)ethoxy]ethyl}-3,4-dibromo-1H-pyrrole-2,5-dione
MFCD27635180

Biological Activity

[Description]:

3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
425.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H14Br2N2O4

[ Molecular Weight ]:
386.037

[ Flash Point ]:
210.9±28.7 °C

[ Exact Mass ]:
383.932007

[ LogP ]:
-0.21

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.602

Related Compounds