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Acid-PEG3-C2-Boc

Names

[ CAS No. ]:
1807539-06-5

[ Name ]:
Acid-PEG3-C2-Boc

[Synonym ]:
2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid
MFCD28015771
3,7,10,13-Tetraoxahexadecan-16-oic acid, 2,2-dimethyl-4-oxo-

Biological Activity

[Description]:

Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.

[2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
423.2±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H26O7

[ Molecular Weight ]:
306.352

[ Flash Point ]:
147.2±19.4 °C

[ Exact Mass ]:
306.167847

[ LogP ]:
0.50

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.457

[ Storage condition ]:
2-8°C

Related Compounds