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EPZ031686

Names

[ CAS No. ]:
1808011-22-4

[ Name ]:
EPZ031686

[Synonym ]:
6-Chloro-2-oxo-N-[(3-endo)-8-({[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl}sulfonyl)-8-azabicyclo[3.2.1]oct-3-yl]-5-indolinecarboxamide
MFCD30181978
1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]-

Biological Activity

[Description]:

EPZ031686 is an orally available SMYD3 inhibitor with an IC50 of 3 nM in cell-free assay.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Research Areas >> Cancer

[References]

[1]. Mitchell LH et al. Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.


[Related Small Molecules]

GSK126 | Tazemetostat (EPZ-6438) | UNC 0642 | GSK343 | Pinometostat (EPZ5676) | 3-Deazaneplanocin A (hydrochloride) | Pemrametostat (GSK3326595) | UNC1999 | BIX-01294 | AZ505 (ditrifluoroacetate) | MS023 | EPZ 004777 | EPZ015666 | EPZ015866(GSK591) | Chaetocin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C26H34ClF3N4O4S

[ Molecular Weight ]:
591.086

[ Exact Mass ]:
590.194153

[ LogP ]:
3.44

[ Index of Refraction ]:
1.603

[ Storage condition ]:
2-8℃

Related Compounds