WT IDH1 Inhibitor 2

Names

[ Name ]:
WT IDH1 Inhibitor 2

Biological Activity

[Description]:

WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor with an IC50 value of 120 nM. WT IDH1 Inhibitor 2 as a mutant R132H IDH1 inhibitor, is an isomer of GSK321 with some wild-type cross reactivity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)

[Target]

IC50: 120 nM (WT IDH1)[1]

[In Vitro]

WT IDH1 Inhibitor 2 (0.1~3 μM; 5 hours; A-498 cells) dose dependent decreases in reductive glutaminolysis[1].

[References]

[1]. Jakob CG, U et al. Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. J Med Chem. 2018;61(15):6647-6657.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₈FN₅O₃

[ Molecular Weight ]:
501.55

Safety Information

[ Hazard Codes ]:
Xi

WT IDH1 Inhibitor 2

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds