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PF06650833

Names

[ CAS No. ]:
1817626-54-2

[ Name ]:
PF06650833

[Synonym ]:
1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy}-7-methoxy-6-isoquinolinecarboxamide
S3F315JJXI
6-Isoquinolinecarboxamide, 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-

Biological Activity

[Description]:

PF06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), and used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> IRAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Research Areas >> Inflammation/Immunology

[References]

[1]. Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32.


[Related Small Molecules]

IRAK-1-4 Inhibitor I | CA-4948 | ginsenoside Rb1 | IRAK4-IN-1 | IRAK inhibitor 1 | IRAK inhibitor 4 | IRAK inhibitor 2 | IRAK inhibitor 3 | IRAK inhibitor 6

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
621.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H20FN3O4

[ Molecular Weight ]:
361.367

[ Flash Point ]:
329.4±31.5 °C

[ Exact Mass ]:
361.143799

[ LogP ]:
0.19

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
2-8℃

Related Compounds