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(Rac)-Calpain Inhibitor XII

Names

[ CAS No. ]:
181769-57-3

[ Name ]:
(Rac)-Calpain Inhibitor XII

[Synonym ]:
N-[(benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(pyridin-2-ylmethyl)amino]hexan-3-yl}leucinamide
N-[(Benzyloxy)carbonyl]-N-{1,2-dioxo-1-[(2-pyridinylmethyl)amino]-3-hexanyl}leucinamide
Carbamic acid, N-[1-[[[1-[1,2-dioxo-2-[(2-pyridinylmethyl)amino]ethyl]butyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Biological Activity

[Description]:

(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki=19 nM), with lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM). (Rac)-Calpain Inhibitor XII has been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C26H34N4O5

[ Molecular Weight ]:
482.572

[ Exact Mass ]:
482.252930

[ PSA ]:
126.49000

[ LogP ]:
3.17

[ Index of Refraction ]:
1.548

Related Compounds