bromopropylate

Names

[ Name ]:
bromopropylate

[Synonym ]:
isopropyl 4,4’-dibromobenzilate
4-Bromo-α-(4-bromophenyl)-α-hydroxybenzeneacetic acid 1-methylethyl ester
Isopropyl bromobenzilate
Folbex VA
propan-2-yl bis(4-bromophenyl)hydroxyacetate
Caswell No. 511A
Benzilic acid, 4,4'-dibromo-, isopropyl ester (8CI)
isopropyl 4,4'-dibromobenzilate
Neoron
Benzeneacetic acid, 4-bromo-α-(4-bromophenyl)-α-hydroxy-, 1-methylethyl ester
Isopropyl-4,4'-dibrombenzilat
propan-2-yl bis(4-bromophenyl)(hydroxy)acetate
ACAROL
1-methylethyl 4-bromo-α-(4-bromophenyl)-α-hydroxybenzeneacetate
propan-2-yl 2,2-bis(4-bromophenyl)-2-hydroxyacetate
Phenisobromolate
EINECS 242-070-7
MFCD00078632
bromopropylate
isopropyl 2,2-bis(4-bromophenyl)-2-hydroxyacetate
4,4'-Dibrombenzilsaeure-isopropylester
4,4'-Dibromobenzilic acid isopropyl ester
Isopropyl bis(4-bromophenyl)(hydroxy)acetate
Ascarol 2E

Biological Activity

[Description]:

Bromopropylate is a pesticide with moderate anti-androgenic activities[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Androgen Receptor

[Target]

Anti-androgenic[1]

[References]

[1]. Mengmeng Ma, et al. Combined Anti-Androgenic Effects of Mixtures of Agricultural Pesticides Using in Vitro and in Silico Methods. Ecotoxicol Environ Saf. 2019 Dec 30;186:109652.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
504.5±45.0 °C at 760 mmHg

[ Melting Point ]:
77ºC

[ Molecular Formula ]:
C₁₇H₁₆Br₂O₃

[ Molecular Weight ]:
428.115

[ Flash Point ]:
258.9±28.7 °C

[ Exact Mass ]:
425.946594

[ PSA ]:
46.53000

[ LogP ]:
5.43

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.601

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD2100000

CHEMICAL NAME :: Benzilic acid, 4,4'-dibromo-, isopropyl ester

CAS REGISTRY NUMBER :: 18181-80-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C17-H16-Br2-O3

MOLECULAR WEIGHT :: 428.15

WISWESSER LINE NOTATION :: ER DXQR DE&VOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Morphological transformation

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 125 mg/kg

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 17,407,1996 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 56,107,1975

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R38

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
DD2100000

[ HS Code ]:
2918199042

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199042

Articles

Gas chromatographic determination of residues of bromopropylate and two of its degradation products in honey.

J. Assoc. Off. Anal. Chem. 67(5) , 896-901, (1984)

An analytical procedure is described for determination of residues of bromopropylate (BP) and its main degradation product 4,4'-dibromobenzophenone (BBP) in honey. The method also allows the determina...

Rapid multi-residue method for the determination of azinphos methyl, bromopropylate, chlorpyrifos, dimethoate, parathion methyl and phosalone in apricots and peaches by using negative chemical ionization ion trap technology.

J. Chromatogr. A. 996(1-2) , 181-7, (2003)

A rapid, selective and sensitive multi-residue method for the determination of six common pesticides in stone fruit samples is described. The proposed method involves the extraction of the pesticides ...

Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides.

Carcinogenesis 11(8) , 1413-7, (1990)

The organochlorine pesticide 1,1'-(2,2,2-trichloroethylidene) bis(4-chlorobenzene) (DDT) and four structural analogues (bromopropylate, chlorobenzilate, dicofol and fenarimol) were investigated for th...