BI-0252

Names

[ Name ]:
BI-0252

Biological Activity

[Description]:

BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> MDM-2/p53

[Target]

IC50: 4 nM (MDM2-p53)[1]

[References]

[1]. Gollner A, et al. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J Med Chem. 2016 Nov 23;59(22):10147-10162.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₂₆Cl₂FN₃O₃

[ Molecular Weight ]:
566.45

BI-0252

Names

Biological Activity

Chemical & Physical Properties

Related Compounds