S-acetyl-PEG6-Boc

Names

[ Name ]:
S-acetyl-PEG6-Boc

[Synonym ]:
MFCD26127816
2-Methyl-2-propanyl 2-oxo-6,9,12,15,18,21-hexaoxa-3-thiatetracosan-24-oate
6,9,12,15,18,21-Hexaoxa-3-thiatetracosan-24-oic acid, 2-oxo-, 1,1-dimethylethyl ester

Biological Activity

[Description]:

S-acetyl-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
522.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₄₀O₉S

[ Molecular Weight ]:
468.602

[ Flash Point ]:
242.0±18.1 °C

[ Exact Mass ]:
468.239288

[ LogP ]:
0.44

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.471

S-acetyl-PEG6-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds