Amino-PEG9-Boc

Names

[ Name ]:
Amino-PEG9-Boc

[Synonym ]:
2-Methyl-2-propanyl 1-amino-3,6,9,12,15,18,21,24,27-nonaoxatriacontan-30-oate
3,6,9,12,15,18,21,24,27-Nonaoxatriacontan-30-oic acid, 1-amino-, 1,1-dimethylethyl ester
MFCD26127807

Biological Activity

[Description]:

Amino-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
576.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₅₁NO₁₁

[ Molecular Weight ]:
541.672

[ Flash Point ]:
91.9±25.0 °C

[ Exact Mass ]:
541.346191

[ LogP ]:
-2.02

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.461

Amino-PEG9-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds