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Mal-PEG8-acid

Names

[ CAS No. ]:
1818294-46-0

[ Name ]:
Mal-PEG8-acid

[Synonym ]:
MFCD26793771
1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid
3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-

Biological Activity

[Description]:

Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
634.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H39NO12

[ Molecular Weight ]:
521.555

[ Flash Point ]:
337.6±31.5 °C

[ Exact Mass ]:
521.247253

[ LogP ]:
-2.88

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.496

Related Compounds