KC 12291 hydrochloride

Names

[ CAS No. ]:
181936-98-1

[ Name ]:
KC 12291 hydrochloride

[Synonym ]:
Xamoterol hemifumarate

Biological Activity

[Description]:

KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Cardiovascular Disease

[References]

[1]. John GW, et al. KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc Drug Rev. 2004 Spring;22(1):17-26.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₈ClN₃O₃S

[ Molecular Weight ]:
449.99

[ Exact Mass ]:
449.15400

[ PSA ]:
84.95000

[ LogP ]:
4.96770

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%