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PIM-447 dihydrochloride

Names

[ CAS No. ]:
1820565-69-2

[ Name ]:
PIM-447 dihydrochloride

[Synonym ]:
2-Pyridinecarboxamide, N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoro-, hydrochloride (1:2)
N-{4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-3-pyridinyl}-6-(2,6-difluorophenyl)-5-fluoro-2-pyridinecarboxamide dihydrochloride
PIM-447 dihydrochloride
PIM-447 (dihydrochloride)

Biological Activity

[Description]:

PIM447 is a pan-PIM kinase ihibitor with Kis of 6, 18, 9 nM for PIM1, PIM2 and PIM3, respectively.

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> Pim
Research Areas >> Cancer

[References]

[1]. Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.

[2]. Burger MT et al. Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J Med Chem. 2015 Nov 12;58(21):8373-86.

[3]. Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Oncotarget. 2016 Aug 20


[Related Small Molecules]

AZD1208 | Pim1/AKK1-IN-1 | SGI-1776 free base | CX-6258 | TP-3654 | Hispidulin | TCS PIM-1 1 | TCS-PIM-1-4a | GDC-0339 | SMI-16a | M-110 | INCB053914 phosphate | 3,3',4',5,6,7-HEXAHYDROXYFLAVONE

Chemical & Physical Properties

[ Molecular Formula ]:
C24H25Cl2F3N4O

[ Molecular Weight ]:
513.383

[ Exact Mass ]:
512.135742

[ Storage condition ]:
2-8℃

Related Compounds