<Suppliers Price>

Acolbifene

Names

[ CAS No. ]:
182167-02-8

[ Name ]:
Acolbifene

[Synonym ]:
(S)-3-(4-carboxybenzyl)willardiine
(aS)-a-Amino-3-((4-carboxyphenyl)methyl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoicacid
(S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol
UBP 282

Biological Activity

[Description]:

Acolbifene (EM652) is a fourth-generation selective estrogen receptor antagonist with a LC50 value of 22±3 nM.

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR
Research Areas >> Cancer

[References]

[1]. Wang T, et al. Recent advances in selective estrogen receptor modulators for breast cancer. Mini Rev Med Chem. 2009 Sep;9(10):1191-201.


[Related Small Molecules]

Elacestrant dihydrochloride | AZD9496 | Kaempferol | XCT 790 | Estrone | GDC-0810 | (20S)-Protopanaxatriol | 27-Hydroxycholesterol | Diethylstilbestrol | PHTPP | 2,3-bis(4-hydroxyphenyl)propionitrile | 4',7-Isoflavandiol | cholesterol | Chrysin | Endoxifen (Z-isomer hydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
651.5ºC at 760mmHg

[ Molecular Formula ]:
C29H31NO4

[ Molecular Weight ]:
457.56

[ Flash Point ]:
347.8ºC

[ PSA ]:
62.16000

[ LogP ]:
6.76680

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds