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DPI-3290

Names

[ CAS No. ]:
182417-73-8

[ Name ]:
DPI-3290

[Synonym ]:
unii-r3uo4y068s
dpi-3290

Biological Activity

[Description]:

DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively。DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

IC50: 0.18 nM (δ-opioid receptor), 0.46 nM (μ-opioid receptor) and 0.62 nM (κ-opioid receptor)[1]


[In Vivo]

DPI-3290 (Org 41793) (intravenous; 0.05 mg/kg) produces a 50% antinociceptive response in rats[1].

[References]

[1]. Gengo PJ, et al. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. J Pharmacol Exp Ther. 2003 Dec;307(3):1221-6.

Chemical & Physical Properties

[ Density]:
1.161±0.06 g/cm3(Predicted)

[ Boiling Point ]:
620.4±55.0 °C(Predicted)

[ Melting Point ]:
144-145 °C

[ Molecular Formula ]:
C30H34FN3O2

[ Molecular Weight ]:
487.60800

[ Exact Mass ]:
487.26400

[ PSA ]:
47.02000

[ LogP ]:
5.35370

[ Storage condition ]:
2-8°C

Related Compounds