Thalidezine

Names

[ Name ]:
Thalidezine

[Synonym ]:
O5-demethyl-hernandezine
5-hydroxy-tetrandrine
Hydroxytetrandrin
(+)-thalidezine

Biological Activity

[Description]:

Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention [1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Law BYK, et al. Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death. Oncotarget. 2017 May 2;8(18):30077-30091.

Chemical & Physical Properties

[ Density]:
1.206g/cm3

[ Boiling Point ]:
735ºC at 760mmHg

[ Molecular Formula ]:
C₃₈H₄₂N₂O₇

[ Molecular Weight ]:
638.74900

[ Flash Point ]:
398.3ºC

[ Exact Mass ]:
638.29900

[ PSA ]:
82.09000

[ LogP ]:
6.74380

[ Vapour Pressure ]:
2.49E-22mmHg at 25°C

[ Index of Refraction ]:
1.595

Thalidezine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds