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4-Fluoro-N-(1H-indol-5-yl)benzamide

Names

[ CAS No. ]:
182564-41-6

[ Name ]:
4-Fluoro-N-(1H-indol-5-yl)benzamide

[Synonym ]:
Benzamide, 4-fluoro-N-1H-indol-5-yl-
4-Fluoro-N-(1H-indol-5-yl)benzamide

Biological Activity

[Description]:

Oct4 inducer-1 (compound OAC-3) is a potent Oct4 activator. Oct4 inducer-1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. Oct4 inducer-1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Stem Cell/Wnt >> Oct3/4

[In Vitro]

Oct4 inducer-1 (compound OAC-3; 1 μM) enhances reprogramming efficiency by activating Oct4-luc reporter and Nanog-luc reporter in embryonic stem cells (ESCs). Oct4 inducer-1 increases induced pluripotent stem cells (iPSC) generation and accelerates the appearance of iPSC-like colonies[1]. Oct4 inducer-1 (1 μM; 4F (OSKM) infected mouse embryonic fibroblast (MEF)) enhances reprogramming efficiency in iSF1 media[1].

[References]

[1]. Hong SY, et, al. Enhancers of induced pluripotent stem cell reprogramming. US20140154805.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
374.9±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H11FN2O

[ Molecular Weight ]:
254.259

[ Flash Point ]:
180.5±22.3 °C

[ Exact Mass ]:
254.085541

[ PSA ]:
44.89000

[ LogP ]:
2.77

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.721

Related Compounds