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Colesevelam Hydrochloride

Names

[ CAS No. ]:
182815-44-7

[ Name ]:
Colesevelam Hydrochloride

[Synonym ]:
colesevelam
2-(chloromethyl)oxirane,prop-2-en-1-amine,N-prop-2-enyldecan-1-amine,trimethyl-[6-(prop-2-enylamino)hexyl]azanium,chloride,hydrochloride

Biological Activity

[Description]:

Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304(4):G371-G380.

[2]. Cabré N, Duan Y, Llorente C, et al. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells. 2021;10(6):1496.

Chemical & Physical Properties

[ Melting Point ]:
>145℃ (dec.)

[ Molecular Formula ]:
(C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl

[ Molecular Weight ]:
618.24900

[ Exact Mass ]:
616.43800

[ PSA ]:
62.61000

[ LogP ]:
5.97450

[ Storage condition ]:
-20°C

Related Compounds