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Lacnotuzumab

Names

[ CAS No. ]:
1831128-32-5

[ Name ]:
Lacnotuzumab

Biological Activity

[Description]:

Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Metabolic Disease
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

[Target]

CSF-1[1]


[In Vivo]

Lacnotuzumab 中和食蟹猴重组和血清衍生形式的 CSF-1，但它不识别啮齿动物或兔的 CSF-1[2]。

[References]

[1]. Kuemmel S, et, al. A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer. Clin Cancer Res. 2022 Jan 1;28(1):106-115.  

[2]. Pognan F, et, al. Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds