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Lactoferricin B (4-14) (bovine) trifluoroacetate salt

Names

[ CAS No. ]:
183476-25-7

[ Name ]:
Lactoferricin B (4-14) (bovine) trifluoroacetate salt

[Synonym ]:
L-Arginyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-tryptophyl-L-arginyl-L-methionyl-L-lysyl-L-lysyl-L-leucylglycine
Glycine, L-arginyl-L-arginyl-L-tryptophyl-L-glutaminyl-L-tryptophyl-L-arginyl-L-methionyl-L-lysyl-L-lysyl-L-leucyl-

Biological Activity

[Description]:

Lactoferricin, bovine is an iron-binding glycoprotein derived from the acidic hydrolysis of bovine lactoferrin. Lactoferricin, bovine has bactericidal, antifungal, antiparasitic, antitumor, antiviral, and immunomodulatory activities[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Lactoferricin, bovine (50 or 100 μg/mL, 24 h) 在软骨细胞中以浓度依赖的方式显著降低 MMP-1、MMP-3 和 MMP-13 的 mRNA 和蛋白水平[1]。 Lactoferricin, bovine (50 μg/mL, 24 h) 可以有效激活 ERK MAPK 和 Akt 通路，从而介导抗炎作用[1]。

[References]

[1]. Dongyao Yan, et al. Bovine lactoferricin is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb;228(2):447-56.   

Chemical & Physical Properties

[ Density]:
1.5±0.0 g/cm3

[ Molecular Formula ]:
C70H113N25O13S

[ Molecular Weight ]:
1544.871

[ Exact Mass ]:
1543.866943

[ LogP ]:
-2.89

[ Index of Refraction ]:
1.681

Related Compounds