Rolziracetam

Names

[ Name ]:
Rolziracetam

[Synonym ]:
CI-911
tetrahydro-6H-pyrrolizine-3,5-dione
tetrahydro-pyrrolizine-3,5-dione
Rolziracetam
3,5-Dioxopyrrolizidine

Biological Activity

[Description]:

Rolziracetam is a nootropic drug of the racetam family and improves short-term memory in rats and monkeys[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Schindler U, et al. Pre-clinical evaluation of cognition enhancing drugs. Prog Neuropsychopharmacol Biol Psychiatry. 1989;13 Suppl:S99-115.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
274.9ºC at 760mmHg

[ Molecular Formula ]:
C₇H₉NO₂

[ Molecular Weight ]:
139.15200

[ Flash Point ]:
130.5ºC

[ Exact Mass ]:
139.06300

[ PSA ]:
37.38000

[ LogP ]:
0.23570

[ Vapour Pressure ]:
0.00526mmHg at 25°C

[ Index of Refraction ]:
1.548

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8000000

CHEMICAL NAME :: 1H-Pyrrolizine-3,5(2H,6H)-dione, dihydro-

CAS REGISTRY NUMBER :: 18356-28-0

BEILSTEIN REFERENCE NO. :: 0121236

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H9-N-O2

MOLECULAR WEIGHT :: 139.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 7 gm/kg/14D-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Musculoskeletal - other changes

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 17,545,1989

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%