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Acid-C2-PEG3-NHS ester

Names

[ CAS No. ]:
1835759-79-9

[ Name ]:
Acid-C2-PEG3-NHS ester

[Synonym ]:
ACID-PEG3-NHS ESTER

Biological Activity

[Description]:

Acid-C2-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
516.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H21NO9

[ Molecular Weight ]:
347.318

[ Flash Point ]:
265.9±32.9 °C

[ Exact Mass ]:
347.121643

[ LogP ]:
-2.71

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.516

Related Compounds