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DBCO-PEG4-amine

Names

[ CAS No. ]:
1840886-10-3

[ Name ]:
DBCO-PEG4-amine

Biological Activity

[Description]:

DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Florinas S, et al. A Nanoparticle Platform To Evaluate Bioconjugation and Receptor-Mediated Cell Uptake Using Cross-Linked Polyion Complex Micelles Bearing Antibody Fragments. Biomacromolecules. 2016 May 9;17(5):1818-33.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H37N3O6

[ Molecular Weight ]:
523.62

[ Storage condition ]:
-20°C

Related Compounds