Coenzyme A Lithiumsalt

Names

[ Name ]:
Coenzyme A Lithiumsalt

[Synonym ]:
MFCD00075848
COENZYME A TRILITHIUM SALT
Coenzyme A (lithium salt)
EINECS 242-317-9

Biological Activity

[Description]:

Coenzyme A (trilithium), a ubiquitous essential cofactor, is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A (trilithium) plays a central role in the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44(2-3):125-53.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₃Li₃N₇O₁₆P₃S

[ Molecular Weight ]:
785.333

[ Exact Mass ]:
785.139771

[ PSA ]:
423.28000

[ LogP ]:
1.01230

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22;S24/25

[ RIDADR ]:
NONH for all modes of transport

Articles

Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.

J. Biol. Chem. 277 , 1128-1138, (2002)

Peroxisomes function in beta-oxidation of very long and long-chain fatty acids, dicarboxylic fatty acids, bile acid intermediates, prostaglandins, leukotrienes, thromboxanes, pristanic acid, and xenob...

Central role of mitochondria in drug-induced liver injury.

Drug Metab. Rev. 44(1) , 34-87, (2011)

A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events cause mitochondrial m...

Hereditary and acquired diseases of acyl-coenzyme A metabolism.

Mol. Genet. Metab. 94 , 4-15, (2008)

Coenzyme A (CoA) sequestration, toxicity or redistribution (CASTOR) is predicted to occur in many hereditary and acquired conditions in which the degradation of organic acyl esters of CoA is impaired....