CL2A

Names

[ CAS No. ]:
1846605-04-6

[ Name ]:
CL2A

Biological Activity

[Description]:

CL2A is a complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology

[Target]

Alkyl/ether


[References]

[1]. Samantha Congreve, et al. Antibody drug conjugates (ADC). Teknisk- naturvetenskaplig fakultet

Chemical & Physical Properties

[ Molecular Formula ]:
C51H79N9O18

[ Molecular Weight ]:
1106.22

Related Compounds