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VU0652835

Names

[ CAS No. ]:
1848252-81-2

[ Name ]:
VU0652835

Biological Activity

[Description]:

VU0652835 is a metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 of 81 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

[Target]

mGluR5:81 nM (IC50)

[References]

[1]. Felts AS, et al. Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorg Med Chem Lett. 2019 Jan 1;29(1):47-50.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₉N₃O₃S

[ Molecular Weight ]:
333.41