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Scabertopin

Names

[ CAS No. ]:
185213-52-9

[ Name ]:
Scabertopin

[Synonym ]:
2-Butenoic acid, 2-methyl-, (3aR,4S,9S,11Z,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester, (2Z)-
(3S,4R,8R,9Z,12S)-10-Methyl-5-methylene-6,14-dioxo-7,13-dioxatricyclo[10.2.1.0]pentadeca-1(15),9-dien-3-yl (2Z)-2-methyl-2-butenoate

Biological Activity

[Description]:

Scabertopin, isolated from the whole plant of Elephantopus scaber[1], is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Liang QL, et al. [Structure modification on sesquiterpene lactones from Elephantopus scaber]. Yao Xue Xue Bao. 2007 Nov;42(11):1159-61.

[2]. Hiradeve SM, et al. A review on pharmacology and toxicology of Elephantopus scaber Linn. Nat Prod Res. 2014;28(11):819-30.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
592.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H22O6

[ Molecular Weight ]:
358.39

[ Flash Point ]:
260.5±30.2 °C

[ Exact Mass ]:
358.141632

[ PSA ]:
78.90000

[ LogP ]:
2.03

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.558

Related Compounds