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TVP1022

Names

[ CAS No. ]:
185517-74-2

[ Name ]:
TVP1022

[Synonym ]:
(S)-N-(2-Propynyl)-2,3-dihydroinden-1-amine
(1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine (S)-Rasagiline S-(-)-N-Propargyl-1-aminoindan
N-PROPARGYL-1(S)-AMINOINDAN
S-PAI
TVP1022

Biological Activity

[Description]:

TVP1022 is the S-isomer of rasagiline, which is an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[References]

[1]. Ertracht O, et al. The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion. Br J Pharmacol. 2011 Jun;163(4):755-69.

[2]. Berdichevski A, et al. TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. J Pharmacol Exp Ther. 2010 Feb;332(2):413-20.


[Related Small Molecules]

Phenelzine (sulfate) | trans-2-Phenylcyclopropylamine hemisulfate salt | Clorgyline hydrochloride | Rosmarinic acid | pargyline hydrochloride | GSK-LSD1 Dihydrochloride | Rasagiline mesylate | Mofegiline hydrochloride | Paeonol | Iproniazid (phosphate) | Safinamide | Minaprine | Nialamide | Desmethoxyyangonin | Eprobemide

Chemical & Physical Properties

[ Molecular Formula ]:
C12H13N

[ Molecular Weight ]:
171.23800

[ Exact Mass ]:
171.10500

[ PSA ]:
12.03000

[ LogP ]:
2.28760

[ Vapour Pressure ]:
0.000816mmHg at 25°C

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

[ RTECS ]:
NK8216500

Related Compounds