NS-8

NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].

Research Areas >> Endocrinology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1]. Animal Model: Rats[1] Dosage: 1, 3 and 10 mg/kg Administration: Intraduodenal administration, intravenous injection Result: Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure). Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude. Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.

[1]. M Tanaka, et al. A novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. BJU Int. 2003 Dec;92(9):1031-6.