(+)-Biotin-SLC

Names

[ CAS No. ]:
1864003-57-5

[ Name ]:
(+)-Biotin-SLC

[Synonym ]:
MFCD09952651
11-({5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)undecanoic acid
Undecanoic acid, 11-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-

Biological Activity

[Description]:

(+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
730.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H41N3O4S

[ Molecular Weight ]:
427.601

[ Flash Point ]:
395.5±28.7 °C

[ Exact Mass ]:
427.250488

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±5.1 mmHg at 25°C

[ Index of Refraction ]:
1.519

Related Compounds