SU5214

Names

[ Name ]:
SU5214

[Synonym ]:
2H-Indol-2-one, 1,3-dihydro-3-[(2-methoxyphenyl)methylene]-, (3Z)-
3-(2-methoxybenzylidene)indolin-2-one
(3Z)-3-(2-Methoxybenzylidene)-1,3-dihydro-2H-indol-2-one

Biological Activity

[Description]:

SU5214 is a potent VEGFR2 inhibitor extracted from patent US5834504A, SU5214, has the IC50s of 14.8 µM (FLK-1) and 36.7 µM (EGFR), respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

Flk-1:14.8 μM (IC50)

[References]

[1]. Tang et al. 3-(2'-halobenzylidenyl)-2-indolinone compounds for the treatment of disease. US5834504A.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
469.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₃NO₂

[ Molecular Weight ]:
251.280

[ Flash Point ]:
237.7±28.7 °C

[ Exact Mass ]:
251.094635

[ LogP ]:
3.42

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
-20℃