N6-Methyladenosine

Names

[ Name ]:
N6-Methyladenosine

[Synonym ]:
N-Methyladenosine
6-methylaminopurine riboside
N(6)-methyladenosine
Adenosine,N-methyl
6-N-Methyladenoside
n6-methyladenosine
6-Methylaminopurine D-riboside
6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
6-Methylaminopurine ribonucleoside
6-Methylaminopurinosine

Biological Activity

[Description]:

N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Others

[In Vitro]

N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion[1]. N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits[2].

[References]

[1]. Wang X, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20.

[2]. Li Y, et al. Genome-wide detection of high abundance N6-methyladenosine sites by microarray. RNA. 2015 Aug;21(8):1511-8.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.85g/cm3

[ Boiling Point ]:
649.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₅N₅O₄

[ Molecular Weight ]:
281.26800

[ Flash Point ]:
346.3ºC

[ Exact Mass ]:
281.11200

[ PSA ]:
125.55000

[ Vapour Pressure ]:
9.86E-18mmHg at 25°C

[ Index of Refraction ]:
1.814

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%