HOPan

Names

[ Name ]:
HOPan

[Synonym ]:
hopantenic acid
HOPA
Homopantothenic acid
4-D-pantoylamino-butyric acid
D-Homopantothenic acid
Hopantenic
4-D-Pantoylamino-buttersaeure
HOPan

Biological Activity

[Description]:

HoPan inhibits phosphopantotenoylcysteine synthetase activity.

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Mostert KJ, et al. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
556ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₉NO₅

[ Molecular Weight ]:
233.26

[ Flash Point ]:
290.1ºC

[ Exact Mass ]:
233.12600

[ PSA ]:
106.86000

[ Vapour Pressure ]:
1.11E-14mmHg at 25°C

[ Index of Refraction ]:
1.508

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES9570000

CHEMICAL NAME :: Butyric acid, 4-(2,4-dihydroxy-3,3-dimethylbutyramido)-, D-(+)-

CAS REGISTRY NUMBER :: 18679-90-8

LAST UPDATED :: 198511

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H19-N-O5

MOLECULAR WEIGHT :: 233.30

WISWESSER LINE NOTATION :: QV3MVYQX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,546,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962

Safety Information

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%