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Bimosiamose disodium

Names

[ CAS No. ]:
187269-60-9

[ Name ]:
Bimosiamose disodium

[Synonym ]:
[1,1'-Biphenyl]-3-acetic acid, 3',3''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-, sodium salt (1:2)
Disodium 2,2'-{1,6-hexanediylbis[6'-(α-D-mannopyranosyloxy)-3',3-biphenyldiyl]}diacetate
Bimosiamose disodium
7AK2FKB9AW
UNII:7AK2FKB9AW

Biological Activity

[Description]:

Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)[1]


[In Vitro]

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].

[In Vivo]

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1] Dosage: 25 mg/kg Administration: Intravenous injection Result: Showed a significant increase in survival compared with controls.

[References]

[1]. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.

Chemical & Physical Properties

[ Molecular Formula ]:
C46H52Na2O16

[ Molecular Weight ]:
906.875

[ Exact Mass ]:
906.305054

Related Compounds