4-Chlorophenylacetic acid

Names

[ Name ]:
4-Chlorophenylacetic acid

[Synonym ]:
EINECS 217-521-6
Acetic acid, 4-chlorophenyl-
(4-Chlorophenyl)acetic acid
4-Chlorobenzeneacetic acid
4-Chlorophenylacetic acid
2-(4-chloro-phenyl)-acetic acid
p-chlorophenylacetate
Acetic acid,(p-chlorophenyl)
4-Cl-phenylacetic acid
p-chlorophenyl acetic acid
Benzeneacetic acid,4-chloro
Benzeneacetic acid, 4-chloro-
2-(4-chlorophenyl)acetic acid
P-CHLOROPHENYLACETIC ACID
2-(p-Chlorophenyl)acetic acid
4-ClPhCH2CO2H
Acetic acid, (p-chlorophenyl)-
MFCD00004344

Biological Activity

[Description]:

4-Chlorophenylacetic acid is a compound belongs to a family of small aromatic fatty acids with anticancer properties. 4-Chlorophenylacetic acid can provide carbon and energy for Pseudomonas sp[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. U Klages, et al. Degradation of 4-chlorophenylacetic Acid by a Pseudomonas Species. J Bacteriol. 1981 Apr;146(1):64-8.

[2]. Neil Sidell, et al. Inhibition of Estrogen-Induced Mammary Tumor Formation in MMTV-aromatase Transgenic Mice by 4-chlorophenylacetate. Cancer Lett. 2007 Jun 28;251(2):302-10.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
294.1±15.0 °C at 760 mmHg

[ Melting Point ]:
102-105 °C(lit.)

[ Molecular Formula ]:
C₈H₇ClO₂

[ Molecular Weight ]:
170.593

[ Flash Point ]:
131.7±20.4 °C

[ Exact Mass ]:
170.013458

[ PSA ]:
37.30000

[ LogP ]:
2.10

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.570

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG0590000

CHEMICAL NAME :: Acetic acid, (p-chlorophenyl)-

CAS REGISTRY NUMBER :: 1878-66-6

BEILSTEIN REFERENCE NO. :: 1072816

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-Cl-O2

MOLECULAR WEIGHT :: 170.60

WISWESSER LINE NOTATION :: QV1R DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H312 + H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;Xi: Irritant;

[ Risk Phrases ]:
R20/21

[ Safety Phrases ]:
S36/37-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AG0590000

[ HS Code ]:
2916340090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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Novel Chryseobacterium sp. PYR2 degrades various organochlorine pesticides (OCPs) and achieves enhancing removal and complete degradation of DDT in highly contaminated soil.

J. Environ. Manage. 161 , 350-7, (2015)

Long term residues of organochlorine pesticides (OCPs) in soils are of great concerning because they seriously threaten food security and human health. This article focuses on isolation of OCP-degradi...

Degradation of 4-chlorophenylacetic acid by a Pseudomonas species.

J. Bacteriol. 146(1) , 64-8, (1981)

Pseudomonas sp. strain CBS3 was able to utilize 4-chlorophenylacetic acid as the sole source of carbon and energy. When this strain was grown with 4-chlorophenylacetic acid, homoprotocatechuic acid wa...

Inhibition of estrogen-induced mammary tumor formation in MMTV-aromatase transgenic mice by 4-chlorophenylacetate.

Cancer Lett. 251(2) , 302-10, (2007)

Treatment of estrogen-sensitive breast cancer with selective estrogen selective modulators (SERMs) and, more recently, aromatase inhibitors has met with wide success. However, antagonism of estrogen r...