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Eptifibatide acetate salt

Names

[ CAS No. ]:
188627-80-7

[ Name ]:
Eptifibatide acetate salt

[Synonym ]:
[(3R,11S,17S,20S,25aS)-11-(4-Carbamimidamidobutyl)-3-carbamoyl-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxodocosahydro-7H-pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosin-17-yl]acetic acid
Integrilin
7H-Pyrrolo[2,1-g][1,2,5,8,11,14,17,20]dithiahexaazacyclotricosine-17-acetic acid, 3-(aminocarbonyl)-11-[4-[(aminoiminomethyl)amino]butyl]docosahydro-20-(1H-indol-3-ylmethyl)-1,9,12,15,18,21-hexaoxo-, (3R,11S,17S,20S,25aS)-
Eptifibatide

Biological Activity

[Description]:

Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.Target: OthersEptifibatide is an anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake (Sistrurus miliarus barbouri). It belongs to the class of the so called arginin-glycin-aspartat-mimetics and reversibly binds to platelets [1, 2].

[Related Catalog]:

Signaling Pathways >> Cytoskeleton >> Integrin
Research Areas >> Cardiovascular Disease
Peptides

[References]

[1]. Amoroso, G., et al., Eptifibatide and abciximab exhibit equivalent antiplatelet efficacy in an experimental model of stenting in both healthy volunteers and patients with coronary artery disease. J Cardiovasc Pharmacol, 2001. 38(4): p. 633-41.

[2]. Schwarz, M., et al., Reversibility versus persistence of GPIIb/IIIa blocker-induced conformational change of GPIIb/IIIa (alphaIIbbeta3, CD41/CD61). J Pharmacol Exp Ther, 2004. 308(3): p. 1002-11.


[Related Small Molecules]

Cilengitide | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt | Arg-Gly-Asp-Ser | CWHM-12 | OSU-T315 | E 7820 | GLPG 0187 | Firategrast | ATN-161 trifluoroacetate salt | Cucurbitacin B | iRGD peptide | Lifitegrast | Zaurategrast | Integrin Antagonist 1 (hydrochloride) | TR 14035

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C35H49N11O9S2

[ Molecular Weight ]:
831.962

[ Exact Mass ]:
831.315613

[ PSA ]:
374.49000

[ LogP ]:
-4.84

[ Index of Refraction ]:
1.735

[ Storage condition ]:
-20°C

Related Compounds