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METHYL TANSHINONATE

Names

[ CAS No. ]:
18887-19-9

[ Name ]:
METHYL TANSHINONATE

[Synonym ]:
(S)-1,6-Dimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydro-phenanthro[1,2-b]furan-6-carboxylic acid methyl ester
methyl tanshinonate

Biological Activity

[Description]:

Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of Mpro enzyme in SARS-CoV (IC50 = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV
Research Areas >> Metabolic Disease

[References]

[1]. Kim DH, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73.  

[2]. Ni L, et al. Qualitative analysis of the roots of Salvia miltiorrhiza and Salvia yunnanensis based on NIR, UHPLC and LC-MS-MS. J Pharm Biomed Anal. 2019 Jun 5;170:295-304.  

[3]. Diniz LRL, et al. Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies. Biomolecules. 2021 Jan 7;11(1):74.  

Chemical & Physical Properties

[ Density]:
1.296±0.06 g/cm3

[ Boiling Point ]:
523.4±50.0 °C at 760 mmHg

[ Melting Point ]:
175-176 °C

[ Molecular Formula ]:
C20H18O5

[ Molecular Weight ]:
338.35

[ Exact Mass ]:
338.11500

[ PSA ]:
73.58000

[ LogP ]:
3.40100

Related Compounds