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Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

Names

[ CAS No. ]:
189275-71-6

[ Name ]:
Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

[Synonym ]:
N-ACETYL-TRP-GLU-HIS-ASPARTINAL
N-Acetyl-L-tryptophyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-histidinamide
AC-WEHD-ALDEHYDE
PASE-INHIBITOR VIII
Acetyl-tryptyl-glutamyl-histidyl-aspartal
AC-TRP-GLU-HIS-ASP-ALDEHYDE
PASE-1 INHIBITOR VIII
AC-TRP-GLU-HIS-ASP-CHO
N-Acetyl-L-tryptophyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxopropan-2-yl]-L-histidinamide
L-Histidinamide, N-acetyl-L-tryptophyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-

Biological Activity

[Description]:

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Inflammation/Immunology

[Target]

Caspase-1:56 pM (Ki)


[References]

[1]. Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007.  

[2]. Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1250.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H33N7O9

[ Molecular Weight ]:
611.60

[ Flash Point ]:
709.9±34.3 °C

[ Exact Mass ]:
611.233948

[ PSA ]:
252.54000

[ LogP ]:
-0.50

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.633

Safety Information

[ WGK Germany ]:
3

Related Compounds