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1-(2,4-DIHYDROXY-6-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE

Names

[ CAS No. ]:
18956-16-6

[ Name ]:
1-(2,4-DIHYDROXY-6-METHOXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE

[Synonym ]:
2',4'-dihydroxy-6'-methoxychalkone
Alpinetinchalkon
4',6'-dihydroxy-2'-methoxychalcone
2',4'-Dihydroxy-6'-methoxychalkon

Biological Activity

[Description]:

Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[Target]

NLRP3


[References]

[1]. Wang K, et al. Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochem Pharmacol. 2018 Sep;155:494-509.

Chemical & Physical Properties

[ Density]:
1.282g/cm3

[ Boiling Point ]:
484.5ºC at 760 mmHg

[ Molecular Formula ]:
C16H14O4

[ Molecular Weight ]:
270.28000

[ Flash Point ]:
182.7ºC

[ Exact Mass ]:
270.08900

[ PSA ]:
66.76000

[ LogP ]:
3.00250

[ Vapour Pressure ]:
5.2E-10mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

Related Compounds