Acid-PEG9-NHS ester

Names

[ Name ]:
Acid-PEG9-NHS ester

[Synonym ]:
31-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-31-oxo-4,7,10,13,16,19,22,25,28-nonaoxahentriacontan-1-oic acid
MFCD28064339
4,7,10,13,16,19,22,25,28-Nonaoxahentriacontan-1-oic acid, 31-[(2,5-dioxo-1-pyrrolidinyl)oxy]-31-oxo-
Acid-dPEG(R)9-NHS ester

Biological Activity

[Description]:

Acid-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
685.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₄₅NO₁₅

[ Molecular Weight ]:
611.633

[ Flash Point ]:
368.1±34.3 °C

[ Exact Mass ]:
611.278931

[ LogP ]:
-4.86

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.503

Acid-PEG9-NHS ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds