Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH

Names

[ CAS No. ]:
189696-20-6

[ Name ]:
Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH

[Synonym ]:
Mca-Asp-Glu-Val-Asp-Ala-Pro-Lys(Dnp)-OH

Biological Activity

[Description]:

Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Apoptosis >> Caspase

[Target]

Caspase-3

[References]

[1]. Fertig Georg. Method for the detection of the apoptosis activated cysteine protease Caspase 3 by specific antibody-binding and fluorescence enzyme assay. EP0955377A1

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀H₆₂N₁₀O₂₂

[ Molecular Weight ]:
1155.08000

[ Exact Mass ]:
1154.40000

[ PSA ]:
487.22000

[ LogP ]:
3.32010

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis.

Nature 380 , 723, (1996)

Binding of Fas ligand or an agonistic anti-Fas antibody induces apoptosis in Fas-bearing cells. The interleukin-1Beta-converting enzyme (ICE) is a cysteine protease that is involved in apoptosis induc...